Biotin-guided anticancer drug delivery with acidity-triggered drug release.
نویسندگان
چکیده
A novel biotin-guided anticancer drug delivery system, prodrug , consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 45 شماره
صفحات -
تاریخ انتشار 2015